Pubblicazioni
- L' attività scientifica si compendia in numerose comunicazioni presentate personalmente a congressi nazionali ed internazionali ed in pubblicazioni sulla principali riviste scientifiche internazionali, attinenti le patologie cardiovascolari
- Particolare attenzione è stata posta allo studio dei meccanismi patogenetici della malattia aterosclerotica ed allo studio dell'invecchiamento cardiovascoalre mediante la ricerca dei rapporti tra nuovi mediatori dell'infiammazione, markers di stress ossidativo e trombosi.
- Alcune ricerche sono poi state dedicate a nuovi aspetti terapeutici delle patologie da malattia aterosclerotica. Particolare attenzione è stata dedicata agli aspetti pleiotropici delle statine, mediante studi in vivo e in vitro e allo studio di meccanismi antiossidanti dei farmaci antiipertensivi.
Elenco Pubblicazioni
Su Pub Med: Clicca qui
1) Pignatelli P, Carnevale R, Cangemi R, Loffredo L, Sanguigni V, Stefanutti C, Basili S, Violi F. "Atorvastatin Inhibits gp91phox Circulating Levels in Patients With Hypercholesterolemia."
Arterioscler Thromb Vasc Biol. 2009 Dec 3
2) Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A, Pignata C, De Mattia D, Martire B, Pietrogrande MC, Martino S, Gambineri E, Soresina AR, Pignatelli P, Martino F, Basili S, Loffredo L.
"Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study."
Circulation. 2009 Oct 20; 120(16):1616-22.
3) Martino F, Loffredo L, Carnevale R, Sanguigni V, Martino E, Catasca E, Zanoni C, Pignatelli P, Violi F. "Oxidative stress is associated with arterial dysfunction and enhanced intima-media thickness in children with hypercholesterolemia: the potential role of nicotinamide-adenine dinucleotide phosphate oxidase."
Pediatrics. 2008 Sep; 122(3):e648-55.
4) Cangemi R, Loffredo L, Carnevale R, Perri L, Patrizi MP, Sanguigni V, Pignatelli P, Violi F "Early decrease of oxidative stress by atorvastatin in hypercholesterolaemic patients: effect on circulating vitamin E."
European Heart Journal. 2008; 29:54-62.
5) Pignatelli P, Sanguigni V, Lenti L, Loffredo L, Carnevale R, Sorge R, Violi F."Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin."
Journal of Thrombosis and Haemostasis 2007; 5:1170-8.
6) Carnevale R, Pignatelli P, Lenti L, Buchetti B, Sanguigni V, Di Santo S, Violi F. "LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes."
FASEB J. 2007; 21:927-34.
7) Pignatelli P, Di Santo S, Buchetti B, Sanguigni V, Brunelli A, Violi F. "Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment.
" FASEB J. 2006; 20:1082-9.
8) Violi F, Sanguigni V, Loffredo L, Carnevale R, Buchetti B, Finocchi A, Tesauro M, Rossi P, Pignatelli P. "Nox2 is determinant for ischemia-induced oxidative stress and arterial vasodilatation: a pilot study in patients with hereditary Nox2 deficiency."
Arterioscleriosis Thrombosis and Vascular Biology. 2006; 26:e131-2.
9) Pignatelli P, Sanguigni V, Buchetti B, Lenti L, Violi F."Early anticoagulant effect of atorvastatin."
Arterioscleriosis Thrombosis and Vascular Biology. 2005; 25:e145.
10) Pignatelli P, Sanguigni V, Sciocca Giordano P, Coco EL, Lenti L, Violi F. ”Vitamin C inhibits platelet expression of CD40 ligand.”
Free Radical Biology and Medicine. 2005; 38(12):1662-6.
11) Sanguigni V, Pignatelli P, Lenti L, Ferro D, Bellia A, Carnevale R, Tesauro M, Sorge R, Lauro R, Violi F. “Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients.”
Circulation 2005; 111(4):412-9.
12) Sanguigni V, Ferro D, Pignatelli P, Del Ben M, Nadia T, Saliola M, Sorge R, Violi F. “CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia.”
Journal of the American College of Cardiology. 2005;45(1):35-42.
13) Pignatelli P, Sanguigni V, Lenti L, Ferro D, Finocchi A, Rossi P, Violi F. “gp91phox-dependent expression of platelet CD40 ligand.
Circulation. 2004; 110(10):1326-9.
14) Germano G, Sanguigni V, Pignatelli P, Caccese D, Lenti L, Ragazzo M, Lauro R, Violi F.“Enhanced platelet release of superoxide anion in systemic hypertension: role of AT1 receptors.
Journal of Hypertension. 2004; 22(6):1151-6.
15) Sanguigni V, Pignatelli P, Caccese D, Pulcinelli FM, Lenti L, Magnaterra R, Martini F, Lauro R, Violi F.“Increased superoxide anion production by platelets in hypercholesterolemic patients.”
Thrombosis and Haemostasis. 2002 ; 87(5):796-801.
16) Pignatelli P, Lenti L, Sanguigni V, Frati G, Simeoni I, Gazzaniga PP, Pulcinelli FM, Violi F. “Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress.”
American Journal of Physiology Heart Circulation Physiology.2003; 284(1):H41-8.
17) Gargiulo P, Caccese D, Pignatelli P, Brufani C, De Vito F, Marino R, Lauro R, Violi F, Di Mario U, Sanguigni V. “Metformin decreases platelet superoxide anion production in diabetic patients.
Diabetes Metabolism Research and Reviews. 2002; 18(2):156-9.
18) Caccese D, Pratico D, Ghiselli A, Natoli S, Pignatelli P, Sanguigni V, Iuliano L, Violi F. “Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation--role of arachidonic acid metabolism.
Thrombosis and Haemostasis. 2000; 83(3):485-90.
19)Sanguigni V, Gallu M, Sciarra L, Del Principe D, Menichelli A, Palumbo G, Cannata D, Strano A. “Effect of amlodipine on exercise-induced platelet activation in patients affected by chronic stable angina.”
Clinical Cardiology. 1999;22(9):575-80.
20) Sanguigni V, Gallu M, Ruffini MP, Strano A. “Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing method. Italian Group for the Study of Atherosclerosis and Dismetabolic Diseases, Rome II Center.”
European Journal of Epidemiology. 1995; 11(1):75-8.
21) Rocchi G, Sordillo P, Sarrecchia C, Sanguigni V.“Therapy and prevention of infective endocarditis”
Cardiologia. 1994; 39(12 Suppl 1):267-74.
22) Sanguigni V, Gallu M, De Cristofaro R, Ruffini MP, Levi C, Sciarra L, Novo S, Strano A. “Effects of physical activity on lipids and coagulation”
Cardiologia. 1994; 39(6):425-31.
23) Sanguigni V, Gallu M, Novo S, Strano A.”Cholesterol and fibrinogen as predictive factors of progressive carotid atherosclerosis.”
International Angiology. 1993; 12(4):335-6.
24) Novo S, Longo B, Liquori M, Abrignani MG, Barbagallo M, Sanguigni V, Barbagallo Sangiorgi G, Strano A. “Silent myocardial ischemia: prevalence, prognostic significance, diagnosis”
Cardiologia. 1993; 38(12 Suppl 1):243-51.
25) Sanguigni V, Gallu M, Strano A. “Incidence of carotid artery atherosclerosis in patients with coronary artery disease.”
Angiology. 1993; 44(1):34-8.
26) Vitarelli A, Scapato A, Sanguigni V, Caminiti MC. “Evaluation of total anomalous pulmonary venous drainage with cross-sectional colour-flow Doppler echocardiography.”
European Heart Journal . 1986; 7(3):190-5.
